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Class of Signs: Vomiting, nausea, diarrhea, and upper gastrointestinal hemorrhage. Severe cases can lead to changes in liver function, dyspnea, loss of consciousness, hallucination, and even death Prevention: The internal use of the ...

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4. Single Antiplatelet Therapy for Patients with Previous ...
The CAPRIE study showed a statistically significant decrease in GI hemorrhage in patients receiving clopidogrel (1.99%) compared with patients receiving aspirin 325 mg (2.66%).2 This represents an NNH of 149, so the clinical ...

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The most frequent locations of life-threatening bleeding were gastrointestinal, intracranial, puncture, and retroperitoneal sites. A post-hoc analysis identified 3 subgroups of patients with less clinical efficacy and greater absolute ...

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7. Single Antiplatelet Therapy for Patients with Previous ...
OBJECTIVE: To determine whether aspirin plus a proton pump inhibitor (PPI) is preferable, from a gastrointestinal bleed (GIB) risk perspective, to clopidogrel in patients who have experienced a GIB while on aspirin and who require ...

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Hemorrhagic: In CAPRIE patients receiving PLAVIX, gastrointestinal hemorrhage occurred at a rate of 2.0%, and required hospitalization in 0.7%. In patients receiving aspirin, the corresponding rates were 2.7% and 1.1%, respectively. ...

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